L. Weiss

Beyond Kaftrio: mechanistic insights to maximize N1303K-CFTR rescue

This study investigates the mechanism of N1303K-CFTR rescue by ELX/TEZ and ETI combotherapy, showing increased protein amounts and activity with potential clinical benefits.

The effect of UVA light/8-methoxypsoralen exposure used in Extracorporeal Photopheresis treatment on platelets and extracellular vesicles.

This study investigates the effects of UVA light and 8-methoxypsoralen on platelets and extracellular vesicles in vitro, finding no significant activation or changes in EV characteristics.

Platelet proteo-transcriptomic profiling validates mediators of thrombosis and proteostasis in patients with myeloproliferative neoplasms

The paper profiles the platelet proteome in MPN patients to identify mediators of thrombosis and proteostasis, validating key transcriptome findings.

Nociception in chicken embryos, Part III: Analysis of movements before and after application of a noxious stimulus

This study examines movements of chicken embryos before and after a noxious stimulus to determine when nociception begins, finding significant beak movement in 15- to 18-day-old embryos.

Nociception in chicken embryos, Part I: Analysis of cardiovascular responses to a mechanical noxious stimulus

This study examines cardiovascular responses to mechanical noxious stimuli in chicken embryos, finding nociceptive responses emerge by ED16-ED18 with lidocaine reducing MAP changes on ED18.

Immunofilaments Provide a Nanoscale Platform for In Vivo T Cell Expansion and Cancer Immunotherapy

This paper introduces immunofilaments that expand T cells in vivo, showing efficacy against melanoma when combined with immune checkpoint blockade.

ROP INTERACTIVE PARTNER b interacts with RACB and supports fungal penetration into barley epidermal cells

The paper identifies RIPb as a downstream interactor of RACB in barley that enhances susceptibility to powdery mildew fungus by localizing to microtubules and the plasma membrane during haustoria formation.

Posttranslational modification of the RHO of plants protein RACB by phosphorylation and cross-kingdom conserved ubiquitination

The paper identifies phosphorylation and ubiquitination of the plant ROP RACB, showing conserved ubiquitination sites across species and their role in protein stability.