S. Bui

Beyond Kaftrio: mechanistic insights to maximize N1303K-CFTR rescue

This study investigates the mechanism of N1303K-CFTR rescue by ELX/TEZ and ETI combotherapy, showing increased protein amounts and activity with potential clinical benefits.

Cysteine enrichment mediates co-option of uricase in reptilian skin and transition to uricotelism

This study identifies a cysteine-rich urate oxidase in chickens that retains urate oxidation but can also regenerate urate, suggesting a repurposed role in reptilian skin and uricotelism.

Evolutionary adaptation from hydrolytic to oxygenolytic catalysis

This paper investigates how the ABH-fold protein evolved to catalyze oxygenation reactions by repurposing its original hydrolytic function through structural and computational analysis.

SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion

This study shows SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion by altering its structure and function.

Golgi structural defect impairs glycosaminoglycan synthesis, sulfation, and secretion

This study shows that disrupting Golgi structure by knocking out GRASP55 and GRASP65 alters glycosaminoglycan synthesis, sulfation, and secretion.

GRASP55 regulates mutant huntingtin unconventional secretion and aggregation

This study shows GRASP55 promotes mutant huntingtin secretion via autophagy and stress conditions, reducing aggregation and toxicity.

Oligomerization of the FliF domains suggests a coordinated assembly of the bacterial flagellum MS ring

This study investigates the oligomerization of FliF domains in Salmonella typhimurium, revealing how RBM1, RBM2, and RBM3 contribute to the assembly of the MS ring through domain interactions.