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IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming

This study shows that IDH1 deficiency causes chromatin state reprogramming in human erythropoiesis by altering H3K79me3 distribution and upregulating SIRT1, leading to impaired erythropoiesis.

An infection and pathogenesis mouse model of SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR)

This study establishes a mouse model using GX_P2V(short_3UTR) to evaluate drug and vaccine efficacy against SARS-CoV-2.

Comprehensive Characterization and Global Transcriptome Analyses of Human Fetal Liver Terminal Erythropoiesis

This study characterizes human fetal liver terminal erythropoiesis through RNA sequencing of primary and cultured erythroblasts and immortalized cell lines, revealing gene expression patterns and pathway changes associated with enucleation.

In vivo evolution of a Klebsiella pneumoniae capsule defect promotes complement-mediated opsono-phagocytosis and persistence during recurrent infection

The paper identifies a capsule defect in K. pneumoniae that enhances complement-mediated opsonophagocytosis and persistence during recurrent infections.

Metabolic plasticity of T-cell therapies: multi-omic profiling of interacting human tumor-infiltrating lymphocytes and autologous tumor adoptive cell therapy

This study profiles the metabolic interactions between TILs and autologous tumor cells in ACT, finding that responder TILs are more efficient at fatty acid oxidation under starvation.

T-cell potential for CD19-expressing malignancies revealed by multi-dimensional single-cell profiling

The paper identifies migration as a cell-intrinsic biomarker for CAR+ T cell efficacy in B-cell malignancies using multi-dimensional single-cell profiling.

Single cell atlas of the neonatal small intestine with necrotizing enterocolitis

This study uses single-cell and bulk RNA sequencing to identify cellular changes and interactions in necrotizing enterocolitis, highlighting inflammatory macrophages, T cells, and epithelial-mesenchymal-immune interactions.

A highly attenuated SARS-CoV-2 related pangolin coronavirus variant has a 104nt deletion at the 3'-terminus untranslated region

This study identifies a highly attenuated SARS-CoV-2 related pangolin coronavirus variant with a 104nt deletion in the 3'-UTR HVR, showing reduced virulence in vitro and in vivo.

Spermidine dampens inflammation by directly inhibiting Th17 cytokine production through a PRDX1 associated antioxidant pathway

This study shows spermidine directly inhibits Th17 cytokine production via PRDX1-dependent antioxidant activity, reducing lung inflammation in mouse models.

Inhibition of aryl hydrocarbon receptor signaling promotes the terminal differentiation of human erythrocytes

This study shows that inhibiting AHR signaling enhances terminal differentiation of human erythrocytes by promoting F-actin remodeling and cytoskeleton maturation.

CD4+ T cell lymphopenia and dysfunction in severe COVID-19 disease is autocrine TNF-α/TNFRI-dependent

The paper shows that autocrine TNF-α/TNFRI signaling drives CD4+ T cell lymphopenia and dysfunction in severe COVID-19, and TNF-α blockade improves outcomes.

Key kinematic features in early training predict performance of adult female mice in a single pellet reaching and grasping task

The paper identifies kinematic features from mouse reaching tasks that predict motor performance and efficiency in adult mice.

The Coxiella burnetii QpH1 plasmid is a virulence factor for colonizing bone marrow-derived murine macrophages

This study shows that the QpH1 plasmid in Coxiella burnetii is essential for colonizing murine macrophages and highlights its role in the bacterium's persistence in rodents.

Functional single-cell profiling identifies that exosomes are associated with increased immune cell infiltration in non-metastatic breast cancer

The paper develops a single-cell technique to profile exosome secretion in breast cancer cells and finds that non-metastatic cells secrete more exosomes, which correlates with better prognosis and immune infiltration.

SARS-CoV-2 and Malayan pangolin coronavirus infect human endoderm, ectoderm and induced lung progenitor cells

This study shows SARS-CoV-2 and GX_P2V can infect human endoderm, ectoderm, and lung progenitor cells derived from hESCs, with some infections blocked by whey protein and Remdesivir.

Single-dose intranasal vaccination elicits systemic and mucosal immunity against SARS-CoV-2

This study develops an intranasal vaccine that induces systemic and mucosal immunity against SARS-CoV-2 in mice, with single-cell RNA-sequencing confirming T and B cell responses in nasal-associated lymphoid tissues.

SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes

This study identifies SF3B1 mutations causing anemia in MDS by inducing missplicing of MAP3K7, leading to reduced p38 MAPK activity and disrupted erythroid differentiation.