Author

L. Zeef

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Mullan· 2 shared E. Jokl· 2 shared J. Pritchett· 2 shared K. Martin· 2 shared K. Piper Hanley· 2 shared K. Simpson· 2 shared N. Hanley· 2 shared V. Athwal· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersCell Biology

A. Mullan

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

PAK1-dependant mechanotransduction enables myofibroblast nuclear adaptation and chromatin organisation during fibrosis

E. Jokl, A. Mullan, K. Simpson, L. Birchall, L. Pearmain, K. Martin, J. Pritchett, R. Shah, N. Hodson, C. Williams, E. Camacho, L. Zeef, I. Donaldson, V. Athwal, N. Hanley, K. Piper Hanley

The paper identifies PAK1-dependent mechanotransduction as critical for myofibroblast nuclear adaptation and chromatin organization during fibrosis, showing its impact on gene regulation and disease progression.

bioRxiv · Mar 31, 2023 · PreprintCell Biology

Novel in-silico predicted matrikines are differential mediators of in vitro and in vivo cellular metabolism

N. Jariwala, M. Ozols, A. Eckersley, B. Mambwe, R. E. B. Watson, L. Zeef, A. Gilmore, L. Debelle, M. Bell, E. J. Bradley, Y. Doush, C. Courage, R. Leroux, O. Peschard, P. Mondon, , M. J. Sherratt

The paper presents an in silico to in vivo pipeline to identify novel matrikines that differentially influence cellular metabolism in vitro and in vivo.

bioRxiv · Mar 17, 2023 · PreprintCell Biology

Zebrafish IL-4-like cytokines and IL-10 suppress inflammation but only IL-10 is essential for gill homeostasis.

A. F. Hurlstone, F. Bottiglione, C. T. Dee, R. Lea, L. Zeef, A. P. Badrock, M. Wane, L. Bugeon, M. J. Dallman, J. E. Allen

The paper investigates the roles of IL-4-like and IL-10 cytokines in zebrafish gill homeostasis and inflammation, finding that IL-10 is essential while IL-4-like cytokines are not.

bioRxiv · Apr 9, 2020Immunology

SOX9 is required for kidney fibrosis and regulates NAV3 to control renal myofibroblast function in mice and humans

S. Raza, E. Jokl, J. Pritchett, K. Martin, K. Su, K. Simpson, A. Mullan, V. Athwal, D. Doherty, L. Zeef, N. Henderson, P. Kalra, N. Hanley, K. Piper Hanley

This study identifies SOX9 as essential for kidney fibrosis and shows it regulates NAV3 to control myofibroblast function in mice and humans.

bioRxiv · Nov 12, 2019 · PreprintCell Biology