N. Hodson

PAK1-dependant mechanotransduction enables myofibroblast nuclear adaptation and chromatin organisation during fibrosis

The paper identifies PAK1-dependent mechanotransduction as critical for myofibroblast nuclear adaptation and chromatin organization during fibrosis, showing its impact on gene regulation and disease progression.

Mechanistic target of rapamycin complex 1 (mTORC1) activity occurs predominantly in the periphery of human skeletal muscle fibers, in close proximity to focal adhesion complexes, following anabolic stimuli

This study shows mTORC1 activity in human skeletal muscle occurs in the periphery, near focal adhesion complexes, after anabolic stimuli like exercise or protein intake.

Protein-carbohydrate ingestion alters Vps34 cellular localization independent of changes in kinase activity in human skeletal muscle

This study shows that protein-carbohydrate ingestion in human skeletal muscle increases Vps34 translocation to the cell periphery and its co-localization with mTOR, without altering Vps34 kinase activity or preventing mTORC1 activation.