PAK1-dependant mechanotransduction enables myofibroblast nuclear adaptation and chromatin organisation during fibrosis
E. Jokl, A. Mullan, K. Simpson, L. Birchall, L. Pearmain, K. Martin, J. Pritchett, R. Shah, N. Hodson, C. Williams, E. Camacho, L. Zeef, I. Donaldson, V. Athwal, N. Hanley, K. Piper Hanley
The paper identifies PAK1-dependent mechanotransduction as critical for myofibroblast nuclear adaptation and chromatin organization during fibrosis, showing its impact on gene regulation and disease progression.
bioRxiv · Mar 31, 2023 · PreprintCell Biology