Structural features of mTORC2 that control substrate-specific activities.
Z. Yu, J. Chen, E. Takagi, F. Wang, X. Liu, L.-M. Jourbert, B. Saha, C. Gleason, M. Jin, C. Li, C. Nowotny, D. Agard, Y. Cheng, D. Pearce
The paper determines the structure of mTORC2 and shows how substrate-specific interactions and conformational changes regulate its activity.
bioRxiv · Feb 3, 2022 · PreprintBiochemistry