M. Jin

Intersectin1 promotes clathrin-mediated endocytosis by organizing and stabilizing endocytic protein interaction networks

This study shows that intersectin1 promotes clathrin-mediated endocytosis by organizing and stabilizing endocytic protein interaction networks rather than initiating CME.

RGS10 deficiency facilitates distant metastasis by inducing epithelial-mesenchymal transition in breast cancer

This study shows RGS10 deficiency promotes breast cancer metastasis via EMT by mechanisms involving lipocalin-2 and miR-539-5p.

Environmental and Historical Determinants of African Horse Sickness: Insights from Predictive Modeling

This study uses predictive modeling to analyze global patterns of African Horse Sickness, identifying high-risk areas and highlighting the impact of climate on disease transmission.

IL-1beta-induced epithelial cell and fibroblast transdifferentiation fuels neutrophil recruitment in chronic rhinosinusitis with nasal polyps

This study identifies IL-1beta-induced cell subsets that promote neutrophil recruitment in CRSwNP and shows IL-1beta inhibition reduces inflammation.

Mitotic waves in frog egg extracts: Transition from phase waves to trigger waves

The paper observes a transition from phase waves to trigger waves in Xenopus egg extracts and shows how these waves coordinate the cell cycle over long distances.

Ciliary length regulation by intraflagellar transport in zebrafish

This study investigates cilia length regulation in zebrafish by analyzing intraflagellar transport (IFT) speed and particle size, finding that longer cilia have faster IFT and that reducing IFT particle size shortens cilia.

Identification of cytokine predominant immunosuppressive class and prognostic risk signatures in glioma

The paper identifies an immunosuppressive class of glioblastoma (IDC) with high anti-inflammatory cytokine expression and poor prognosis, suggesting resistance to immune checkpoint blockade therapy.

MGA deletion leads to Richter's transformation via modulation of mitochondrial OXPHOS

This study shows that MGA deletion drives Richter's transformation by modulating mitochondrial OXPHOS through the MGA-NME1 axis, suggesting a new therapeutic target.

Two teosintes made modern maize

This study clarifies the origin of modern maize by showing it resulted from an ancient admixture between domesticated maize and Zea mays ssp. mexicana around 5300 years ago, contributing to genetic and phenotypic diversity.

Pathway and mechanism of tubulin folding mediated by TRiC/CCT conjugated with its ATPase cycle revealed by cryo-EM

This study reveals the pathway and mechanism of TRiC-mediated tubulin folding using cryo-EM structures and XL-MS, showing how tubulin is stabilized during the ATPase cycle.

Structural basis of plp2-mediated cytoskeletal protein folding by TRiC/CCT

This study uses cryo-EM to reveal structural details of TRiC/CCT-mediated folding of tubulin and actin with plp2, showing how plp2 coordinates substrate translocation and folding.

A novel inovirus reprograms metabolism and motility of marine Alteromonas

This study isolates and characterizes a novel inovirus, {phi}AFP1, from Alteromonas abrolhosensis, revealing its impact on host metabolism and motility through transcriptomic analysis.

Metabolomics and transcriptomics reveal the response mechanisms of Mikania micrantha to Puccinia spegazzinii infection

This study investigates how Mikania micrantha responds to Puccinia spegazzinii infection using metabolomics and transcriptomics, identifying changes in metabolites and gene expression.

Global Spatial Transcriptome of Macaque Brain at Single-Cell Resolution

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

Structural features of mTORC2 that control substrate-specific activities.

The paper determines the structure of mTORC2 and shows how substrate-specific interactions and conformational changes regulate its activity.

An innovative approach to using an intensive field course to build scientific and professional skills

This paper describes a field course that develops scientific and professional skills through iterative project-based learning and evaluation.

Rescue of stalled clathrin-mediated endocytosis by asymmetric Arp2/3-mediated actin assembly

The paper investigates how asymmetric actin assembly rescues stalled clathrin-mediated endocytosis by analyzing endocytic dynamics and protein geometry using advanced imaging and computational methods.

CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.

The paper uses cryo-EM and AlphaFold2 to determine the structure of SARS-CoV-2 Nsp2, revealing its zinc-binding site and potential interactions with host proteins.

Portrait of a genus: the genetic diversity of Zea

This study maps genetic diversity across Zea species, identifying millions of variants and adaptive genes, and demonstrates their utility in breeding.

Development of a chemiluminescence immunoassay to accurately detect African swine fever virus antibodies in serum

This paper develops a chemiluminescence immunoassay for detecting ASFV antibodies in serum, showing high specificity, sensitivity, and consistency with a commercial kit.

Cryo-EM study on the homo-oligomeric ring formation of yeast TRiC/CCT subunits reveals TRiC ring assembly mechanism

This study uses cryo-EM to reveal the mechanism of TRiC/CCT ring assembly in yeast, showing subunit-specific roles and ATP-driven assembly dynamics.

Rapid spread of a symbiotic virus in a major crop pest following wide-scale adoption of Bt-cotton in China

The paper shows that Bt-cotton adoption in China increased the prevalence of a symbiotic virus in the cotton bollworm, enhancing its resistance to Bt-cotton.

An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation

This paper develops a potent synthetic nanobody that neutralizes SARS-CoV-2 by locking its Spike protein in an inactive conformation, enabling aerosol delivery as a prophylactic or therapeutic agent.

Evolutionarily related small viral fusogens hijack distinct but modular actin nucleation pathways to drive cell-cell fusion

This study shows that two FAST proteins use distinct actin nucleation pathways to drive cell-cell fusion, but their cytoplasmic tails are modular and functionally interchangeable.

SARS-CoV-2 neutralizing serum antibodies in cats: a serological investigation

The paper investigates SARS-CoV-2 infection in cats by detecting serum antibodies, finding 14.7% of post-outbreak samples positive for RBD and 11 with neutralizing antibodies.

P4HA2 is associated with prognosis, promotes proliferation, invasion, migration and EMT in glioma

This study shows P4HA2 is overexpressed in glioma and promotes cancer progression by enhancing proliferation, invasion, migration, and EMT, while also regulating the PI3K/AKT pathway through collagen expression.

A complex structure of arrestin-2 bound to a G protein-coupled receptor

The paper reports the structure of arrestin-2 bound to neurotensin receptor 1, revealing a novel orientation that enables coupling to GPCRs lacking a C-terminal tail.

Non-antibiotic antimicrobial triclosan induces multiple antibiotic resistance through genetic mutation

This study shows that triclosan exposure induces antibiotic resistance in E. coli through genetic mutations and gene expression changes.