B. Saha

MerTK-dependent efferocytosis by monocytic-MDSCs mediates resolution of post-lung transplant injury

This study shows that MerTK-dependent efferocytosis by monocytic-MDSCs reduces post-lung transplant ischemia-reperfusion injury.

TBK1 is ubiquitinated by TRIM5alpha to assemble mitophagy machinery

The paper shows TRIM5 ubiquitinates TBK1 to assemble mitophagy machinery on damaged mitochondria, essential for both Parkin-dependent and independent mitophagy.

Conserved cardiolipin-mitochondrial ADP/ATP carrier interactions assume distinct structural and functional roles that are clinically relevant

This study investigates the role of cardiolipin interactions in the ADP/ATP carrier using yeast Aac2, showing that disrupting these interactions impairs structure and transport activity, with clinical relevance in ANT1 mutations.

Structural features of mTORC2 that control substrate-specific activities.

The paper determines the structure of mTORC2 and shows how substrate-specific interactions and conformational changes regulate its activity.

Hemocyte Differentiation to the Megacyte Lineage Enhances Mosquito Immunity Against Plasmodium

The paper shows that silencing Cactus in Anopheles gambiae increases megacyte production, enhancing mosquito immunity against Plasmodium through microvesicle release and complement activation.

Interactomic analysis reveals a new homeostatic role for the HIV restriction factor TRIM5α in mitophagy

The paper identifies a novel role for TRIM5α in mitophagy, showing it regulates mitochondrial quality control and prevents cell death under mitochondrial stress.

A non-canonical role for the autophagy machinery in anti-retroviral signaling mediated by TRIM5α.

This paper shows autophagy proteins are required for TRIM5α to activate antiviral signaling and establish an antiviral state.