Cell BiologybioRxivPreprint
Loss of endothelial ALK1 signaling induces the emergence of a KIT+ angiogenic endothelial cluster driving brain arteriovenous malformations
Elise Drapé, Lauranne Carrier, Gaël Cagnone…·Alexandre Dubrac
This study identifies a novel angiogenic endothelial cluster driven by loss of ALK1 signaling in brain arteriovenous malformations (bAVMs) and shows that KIT inhibition prevents bAVM formation.