Cancer BiologybioRxivPreprint
T-ALL Proliferation Relies on Glutamine Uptake and EAAT1-dependent Conversion of Glutamine to Aspartate and Nucleotides
V. S. Stanulovic, S. Al Omair, M. A. C. Reed…·M. Hoogenkamp
This study identifies EAAT1 as a critical target for T-ALL treatment by showing its role in glutamine conversion to nucleotides and aspartate essential for cell proliferation.
DOI 10.1101/2020.02.08.939694