M. A. Cahill

The paper presents a second crystal structure of an archaeal cytb5M domain, supporting the hypothesis that MAPR-like heme orientation originated from prokaryotic ancestors.

The paper identifies a new class of prokaryotic cytochrome b5 proteins related to eukaryotic MAPR family members and suggests a bacterial origin for PGRMC1 and CYP51A.

This study shows that PGRMC1 phosphorylation mutants alter genomic stability, CpG methylation, and cell metabolism, suggesting a role in cellular plasticity and tissue differentiation.

This study shows that altering PGRMC1 phosphorylation in cancer cells affects energy metabolism, mitochondrial function, and tumor growth.

This paper traces the evolutionary origins of MAPR family proteins, showing their presence in the common ancestor of Opisthokonta and their functional diversification in animals.