R. S. Heyderman

This study investigates how pneumococcal lipoproteins mediate epithelial microinvasion and finds that differential lipoprotein repertoires do not significantly impact microinvasion, suggesting post-translational modifications may be responsible.

This paper shows that disease-attenuated pneumococcal mutants retain epithelial microinvasion but show reduced transmigration and altered inflammatory responses.

This study shows that KDM6B modulates the host response to Streptococcus pneumoniae by altering chromatin structure at the IL-11 promoter, affecting NF-κB activation.

This study shows that Streptococcus pneumoniae colonizes human mucosa via microinvasion, triggering epithelial innate immunity and influencing bacterial clearance.

The paper uses mass cytometry to analyze nasal immune cells after pneumococcal challenge, identifying immune changes linked to colonization and host-pathogen interactions.