M. Amrute-Nayak

This study compares the chemo-mechanical properties of cardiac ventricular and slow skeletal myosins with the same heavy chain isoform, finding distinct kinetic and mechanical behaviors.

The paper shows that MLC1sa in soleus myosin slows actin gliding compared to MLC1sb/v in ventricular myosin, likely due to increased actin affinity and reduced dissociation rate.

The paper investigates how regulatory light chains (RLCs) influence the functional diversity of myosin-II isoforms by swapping RLCs with different myosin heavy chains and measuring changes in actin filament sliding velocity.