Author

M. Azfar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. Van den Haute· 3 shared P. Vangheluwe· 3 shared S. H. L. Verhelst· 2 shared A. Bongers· 1 shared A. Karsa· 1 shared B. Liu· 1 shared C. Mayoh· 1 shared D. Spurling· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCancer Biology

C. Van den Haute

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The polyamine transporter ATP13A3 mediates DFMO-induced polyamine uptake in neuroblastoma

M. Azfar, W. Gao, C. Van den Haute, L. Xiao, M. Karsa, R. Pandher, E. Ronca, A. Bongers, A. Karsa, D. Spurling, X. Guo, C. Mayoh, M. R. Burns, S. H. L. Verhelst, M. D. Norris, , K. Somers

This study identifies ATP13A3 as a polyamine transporter mediating DFMO-induced polyamine uptake in neuroblastoma, highlighting it as a therapeutic target.

bioRxiv · Feb 20, 2024 · PreprintCancer Biology

ATP13A3 Variants Promote Pulmonary Arterial Hypertension by Disrupting Polyamine Transport

B. Liu, M. Azfar, E. Legchenko, J. A. West, S. Martin, C. Van den Haute, V. Baekelandt, J. Wharton, L. Howard, M. Wilkins, P. Vangheluwe, N. W. Morrell, P. D. Upton

This study identifies ATP13A3 as a polyamine transporter whose deficiency leads to endothelial dysfunction and pulmonary arterial hypertension.

bioRxiv · Aug 29, 2023 · PreprintCell Biology

Novel green fluorescent polyamines to analyze ATP13A2 and ATP13A3 activity in the mammalian polyamine transport system

M. C. Houdou, N. Jacobs, J. Coene, M. Azfar, R. Vanhoutte, C. Van den Haute, J. Eggermont, V. Daniels, S. H. L. Verhelst, P. Vangheluwe

The paper develops green fluorescent polyamine analogs to study ATP13A2 and ATP13A3 polyamine transport activity and identifies structure-activity relationships for isoform-specific transport.

bioRxiv · Dec 15, 2022Biochemistry