M. Baumgartner

MAP4 kinase-regulated reduced CLSTN1 expression in medulloblastoma is associated with increased invasiveness

This study shows that reduced CLSTN1 expression, regulated by MAP4 kinase, increases invasiveness in medulloblastoma by affecting cell-cell interactions and growth factor responses.

Evolutionary innovation in conserved regulatory elements across the mammalian tree of life

The paper identifies accelerated evolution in conserved enhancer elements across mammals and links it to regulatory function turnover and developmental gene modifications.

Repression of Aurora kinase B prevents growth and tissue invasion in medulloblastoma

This study identifies AURKB as a therapeutic target in medulloblastoma, showing that its inhibition in the tissue context effectively restricts tumor growth and invasiveness, comparable to irradiation.

CD155 and EndoA1 mediate growth and tissue invasion downstream of MAP4K4 in medulloblastoma cells

This study identifies CD155 and EndoA1 as downstream effectors of MAP4K4 that regulate medulloblastoma cell growth and tissue invasion through changes in the plasma membrane proteome.

Striatin 3 and MAP4K4 cooperate towards oncogenic growth and tissue invasion in medulloblastoma

This study identifies STRN3 and MAP4K4 as cooperating factors that promote medulloblastoma growth and invasion by modulating Hippo signaling and PKCθ/VASP pathways.

Evolution of Honey Resistance in Experimental Populations of Bacteria Depends on the Type of Honey, and Has no Major Side Effects for Antibiotic Susceptibility

This study isolates honey-resistant E. coli mutants and finds limited resistance development with small effects on antibiotic susceptibility.

Human-associated microbiota suppress invadingbacteria even under disruption by antibiotics

The paper shows that human-associated microbiota suppress invading antibiotic-resistant bacteria, even after antibiotic exposure, with suppression strength linked to donor-specific community composition.

Microbial community composition interacts with local abiotic conditions to drive colonization resistance in human gut microbiome samples

Combining antibiotics with antivirulence compounds can have synergistic effects and reverse selection for antibiotic resistance in Pseudomonas aeruginosa

This study combines antivirulence compounds with antibiotics to treat Pseudomonas aeruginosa infections, finding synergistic effects and reduced resistance selection in some cases.

Resident microbial communities inhibit growth and antibiotic resistance evolution of Escherichia coli in human gut microbiome samples

This study shows that resident gut microbial communities suppress growth and prevent antibiotic resistance evolution in E. coli, even when resistance genes are present in the community.

Structural basis of human 5,10-methylenetetrahydrofolate reductase (MTHFR) regulation by phosphorylation and S-adenosylmethionine inhibition

This study presents the 2.5 Å resolution crystal structure of human MTHFR, revealing its architecture and how phosphorylation and SAM binding regulate its activity.