Author

S. Lutz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Bioengineering· 2 Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:proteomics· 3 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. H. Ahrens· 2 shared D. S. Froese· 2 shared T. Suormala· 2 shared A. Chaikuad· 1 shared A. Finlayson· 1 shared A. Krebber· 1 shared A. M. Knight· 1 shared A. Muik· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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2 shared papersMicrobiology

C. H. Ahrens

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Hydrophilic/ Omniphobic droplet arrays for high-throughput and quantitative enzymology

B. Lee, F. Sunden, M. Miller, B. Pak, A. Krebber, S. Lutz, P. M. Fordyce

This paper introduces DA-MEK, a high-throughput platform for enzyme variant screening and kinetic analysis using droplet arrays, demonstrating accurate and efficient measurement of catalytic efficiencies.

bioRxiv · Jul 19, 2024Bioengineering

Evolving a High-Performance Terminal Deoxynucleotidyl Transferase for Enzymatic DNA Synthesis

S. Forget, M. Krawczyk, A. M. Knight, C. Ching, R. Copeland, N. Mahmoodi, M. Mayo, J. Nguyen, A. Tan, M. G. Miller, J. Vroom, S. Lutz

This paper evolves a terminal deoxynucleotidyl transferase for enzymatic DNA synthesis using modified substrates, showing improved activity, template promiscuity, and thermostability.

bioRxiv · Jun 24, 2024 · PreprintBioengineering

High-throughput Tn-seq screens identify both known and novel Pseudomonas putida KT2440 genes involved in metal resistance

K. Royet, L. Kergoat, S. Lutz, C. Oriol, N. Parisot, C. Schori, C. H. Ahrens, A. Rodrigue, E. Gueguen

This study uses Tn-seq to identify metal resistance genes in Pseudomonas putida, revealing both known and novel genes involved in cadmium, copper, and cobalt resistance.

bioRxiv · Apr 12, 2024Microbiology

The Hidden Biocatalytic Potential of the Old Yellow Enzyme Family

D. W. White, S. Iamurri, P. Keshavarz-Joud, T. Blue, J. N. Copp, S. Lutz

The paper identifies and characterizes novel OYE enzymes with enhanced biocatalytic activity and expanded substrate scope using bioinformatics and synthetic biology.

bioRxiv · Jul 10, 2023Biochemistry

Pantothenate auxotrophy in a naturally occurring biocontrol yeast

M. P. Rueda Mejia, R. A. Ortiz-Merino, S. Lutz, C. H. Ahrens, M. Kuenzler, F. M. Freimoser

The paper identifies a pantothenate auxotrophic Hanseniaspora meyeri isolate with strong biocontrol activity against plant pathogens, suggesting its auxotrophy may serve as a biocontainment strategy.

bioRxiv · Dec 14, 2022Microbiology

Omicron breakthrough infection drives cross-variant neutralization and memory B cell formation

J. Quandt, A. Muik, N. Salisch, B. G. Lui, S. Lutz, K. Krueger, A.-K. Wallisch, P. Adams-Quack, M. Bacher, A. Finlayson, O. Ozhelvaci, I. Vogler, K. Grikscheit, S. Hoehl, U. Goetsch, , U. Sahin

bioRxiv · Apr 1, 2022 · PreprintImmunology

Genetic, structural, and functional analysis of mutations causing methylmalonyl-CoA epimerase deficiency

K. Heuberger, H. J. Bailey, P. Burda, A. Chaikuad, E. Krysztofinska, T. Suormala, C. Buerer, S. Lutz, B. Fowler, D. S. Froese, W. W. Yue, M. R. Baumgartner

The paper identifies ten new patients with MCEE deficiency, analyzes mutations in the MCEE gene, and reveals structural and functional defects in the enzyme caused by these mutations.

bioRxiv · Nov 30, 2018Biochemistry

Structural basis of human 5,10-methylenetetrahydrofolate reductase (MTHFR) regulation by phosphorylation and S-adenosylmethionine inhibition

D. S. Froese, J. Kopec, E. Rembeza, G. A. Bezerra, A. Oberholzer, T. Suormala, S. Lutz, R. Chalk, O. Borkowska, M. Baumgartner, W. Yue

This study presents the 2.5 Å resolution crystal structure of human MTHFR, revealing its architecture and how phosphorylation and SAM binding regulate its activity.

bioRxiv · Feb 26, 2018Biochemistry