B. Viollet

Direct pharmacological AMPK activation inhibits mucosal SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy flux and the type I IFN response

This paper shows that MK-8722, a direct AMPK activator, inhibits SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy, and enhancing type I IFN response, even when applied post-exposure.

Exercise training adaptations in liver glycogen and glycerolipids require hepatic AMP-activated protein kinase in mice

This study shows that AMPK is necessary for exercise-induced liver adaptations in glycogen and lipid metabolism in mice.

AMPK deficiency in smooth muscles causes persistent pulmonary hypertension after birth and premature death

This study shows that AMPK-1/2 deficiency in smooth muscles leads to persistent pulmonary hypertension and premature death in mice, with no systemic vasculopathy.

The hypoxic ventilatory response is facilitated by the activation of Lkb1-AMPK signalling pathways downstream of the carotid bodies

This study shows that Lkb1-AMPK signaling, but not CaMKK2, is essential for the hypoxic ventilatory response downstream of the carotid bodies.