J. Dubuisson

Direct pharmacological AMPK activation inhibits mucosal SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy flux and the type I IFN response

This paper shows that MK-8722, a direct AMPK activator, inhibits SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy, and enhancing type I IFN response, even when applied post-exposure.

CGRP inhibits SARS-CoV-2 infection of bronchial epithelial cells and its pulmonary levels correlate with viral clearance in critical COVID-19 patients

Biosynthetic proteins targeting the SARS-CoV-2 spike as anti-virals

This paper identifies biosynthetic proteins (Reps) that bind the SARS-CoV-2 spike RBD and neutralize the virus, including variants, with high potency and stability.

Characterization of the hepatitis E virus replicase

This study characterizes the hepatitis E virus replicase by inserting V5 epitopes into ORF1 and identifying its localization and processing during replication.

The Endocytic Recycling Compartment Serves as a Viral Factory for Hepatitis E Virus

This study identifies the endocytic recycling compartment as a site where HEV forms membrane networks, revealing a novel viral factory structure.

A photoactivable natural product with broad antiviral activity against enveloped viruses including highly pathogenic coronaviruses

This paper identifies pheophorbide a as a light-activated natural antiviral effective against SARS-CoV-2, MERS-CoV, and other enveloped viruses by inhibiting viral entry and replication.

Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice

This paper identifies clofoctol as an antiviral against SARS-CoV-2, showing it inhibits viral replication and reduces lung pathology in mice.

An Arginine-Rich Motif in the ORF2 Capsid Protein Regulates the Hepatitis E Virus Lifecycle and Interactions with the Host Cell

This study identifies an Arginine-Rich Motif in the HEV ORF2 capsid protein that regulates its subcellular localization, functionality, and interactions with host cells, revealing its central role in the HEV lifecycle.

Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal coronaviruses

The paper performs bidirectional CRISPR screens to identify host factors regulating SARS-CoV-2, MERS-CoV, and seasonal coronaviruses, revealing new anti-viral proteins and general coronavirus cofactors.

Efficient culture of SARS-CoV-2 in human hepatoma cells enhances viability of the virus in human lung cancer cell lines permitting the screening of antiviral compounds

This paper adapts SARS-CoV-2 to replicate more efficiently in human cells, enabling antiviral compound screening across multiple cell lines.

Theaflavins, polyphenols of black tea, inhibit entry of hepatitis C virus

This study shows that theaflavins from black tea inhibit HCV entry in a dose-dependent manner and show additive effects with existing antivirals.