M. Bonnet

A Mimicry-Based Strategy Between Human and Commensal Antigens for the Development of a New Family of Immune Therapies for Cancer

This paper introduces OncoMimics, a peptide-based immunotherapy using molecular mimicry between commensal bacterial and tumor antigens to induce cross-reactive T cell responses, showing early clinical success in glioblastoma.

Ca2+ Regulation of Myosin II and Myosin VI during Rupture of the Shigella-Containing Vacuole

The paper shows that Ca2+ influx regulates actin dynamics and myosin II/VI activity to facilitate Shigella vacuole rupture.

Duox and Jak/Stat signalling influence disease tolerance in Drosophila during Pseudomonas entomophila infection

This study shows that Duox and Jak/Stat signaling affect disease tolerance in Drosophila during Pseudomonas entomophila infection, with sex-specific effects.

Lactobacillus rhamnosus Lcr35(R) as an effective treatment for preventing Candida albicans infection in preclinical models: first mechanistical insights

This study shows that Lactobacillus rhamnosus Lcr35(R) prevents Candida albicans infection in vitro and in vivo by inhibiting pathogen growth, adhesion, and virulence while activating host immune pathways.

A Gender-Dependent Molecular Switch of Inflammation via MyD88/Estrogen Receptor-alpha Interaction

The paper identifies a gender-dependent molecular switch involving MyD88 and estrogen receptor-alpha that modulates inflammation.

A novel multi SNP based method for the identification of subspecies and associated lineages and sub-lineages of the Mycobacterium tuberculosis complex by whole genome sequencing

This paper introduces SNP-IT, a method using whole genome sequencing to identify subspecies and lineages of Mycobacterium tuberculosis complex, revealing high prevalence of M. orygis in UK clinical isolates.