Author

A. Houdusse

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 3 Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell signaling & trafficking· 4 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Assay:structural biology· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2

Frequent Co-Authors

C. Kikuti· 4 shared D. Auguin· 3 shared D. Moussaoui· 3 shared J. Robert-Paganin· 3 shared H. Sirkia· 2 shared L. Velikovsky· 2 shared A. A. Mohammed Khalid· 1 shared A. Asenjo· 1 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersBiochemistry

C. Kikuti

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Author profile →

10 papers

Recent·Most cited

A weak coupling mechanism mediates the recovery stroke of myosin VI: a free energy simulation and string method analysis

F. E. C. Blanc, A. Houdusse, M. Cecchini

This paper uses free energy simulations and the string method to analyze the recovery stroke of myosin VI, showing that lever-arm re-priming is driven by thermal fluctuations and weakly coupled to ATP hydrolysis.

bioRxiv · Oct 2, 2023 · PreprintBiophysics

MiniBAR/KIAA0355 is a dual Rac and Rab effector required for ciliogenesis

R. Shaughnessy, M. Serres, S. Escot, H. Hammich, F. Cuvelier, A. Salles, M. Rocancourt, Q. Verdon, A.-L. Gaffuri, Y. Sourigues, G. Malherbe, L. Velikovsky, F. Chardon, J.-Y. Tinevez, I. Callebaut, , A. Echard

This study identifies MiniBAR as a dual Rac and Rab effector essential for ciliogenesis, showing its role in coordinating actin dynamics and membrane trafficking.

bioRxiv · Jul 24, 2023 · PreprintCell Biology

How Myosin VI Traps its Off-State, is Activated and Dimerizes

L. Canon, C. Kikuti, V. J. Planelles-Herrero, T. Lin, F. Mayeux, H. Sirkia, Y. i. Lee, L. Heidsieck, L. Velikovsky, A. David, X. Liu, D. Moussaoui, E. Forest, P. Hook, K. J. Petersen, , A. Houdusse

This study investigates how Myosin VI is trapped in its off-state, activated, and dimerizes through structural and functional analyses of its interactions with partners.

bioRxiv · Jun 30, 2023Biochemistry

Cryo-EM structure of the folded-back state of human β-cardiac myosin

A. Grinzato, D. Auguin, C. Kikuti, N. Nandwani, D. Moussaoui, D. Pathak, E. Kandiah, K. M. Ruppel, J. A. Spudich, A. Houdusse, J. Robert-Paganin

The paper reports the 3.6 Å cryo-EM structure of the folded-back IHM state of human β-cardiac myosin, revealing HCM mutation hotspots and structural differences from smooth muscle myosin IHMs.

bioRxiv · Apr 15, 2023 · PreprintBiophysics

Nucleotide-free structures of Kif20A illuminate the atypical allostery in this mitotic kinesin-6

F. M. Ranaivoson, V. Crozet, M. Benoit, A. A. Mohammed Khalid, C. Kikuti, H. Sirkia, A. El Marjou, A. Asenjo, H. Sosa, C. Schmidt, S. Rosenfeld, A. Houdusse

This paper presents the first high-resolution structure of Kif20A's motor domain, revealing structural features and allostery mechanisms that explain its atypical motility and ATPase activity.

bioRxiv · Nov 10, 2022 · PreprintBiochemistry

High-resolution structures of the actomyosin-V complex in three nucleotide states provide insights into the force generation mechanism

S. Pospich, L. Sweeney, A. Houdusse, S. Raunser

The paper reports high-resolution cryo-EM structures of actomyosin-V in three nucleotide states, revealing structural transitions and insights into force generation.

bioRxiv · Sep 7, 2021Biochemistry

VASP mediated actin dynamics activate and recruit a filopodia myosin

A. L. Arthur, A. Crawford, A. Houdusse, M. A. Titus

The paper shows that VASP-mediated actin polymerization activates and recruits a myosin to drive filopodia initiation in Dictyostelium.

bioRxiv · Mar 16, 2021Cell Biology

Kinesin-6 Klp9 orchestrates spindle elongation by regulating microtubule sliding and growth

L. K. Krüger, M. Gelin, L. Ji, C. Kikuti, A. Houdusse, M. Thery, L. Blanchoin, P. Tran

This study identifies Klp9's dual role in regulating microtubule sliding and growth during anaphase B spindle elongation in S. pombe.

bioRxiv · Feb 17, 2021Cell Biology

Structure of Full Length Plasmodium Myosin A and its light chain PfELC, dual targets against malaria parasite pathogenesis

D. Moussaoui, J. P. Robblee, D. Auguin, E. B. Krementsova, S. Haase, T. C. A. Blake, J. Baum, J. Robert-Paganin, K. M. Trybus, A. Houdusse

The paper presents the full-length structure of Plasmodium falciparum Myosin A (PfMyoA) and its light chain PfELC, revealing interactions critical for motor function and identifying PfELC as a potential antimalarial target.

bioRxiv · Jun 30, 2020 · PreprintBiochemistry

Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition

J. Robert-Paganin, D. Auguin, A. Houdusse

This study identifies how different HCM mutations affect cardiac myosin function and auto-inhibition, leading to hypertrophic cardiomyopathy through varied molecular mechanisms.

bioRxiv · May 17, 2018Biophysics