Author

M. Brameshuber

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:fluorescence / live-cell microscopy· 3 Approach:microscopy & imaging analysis· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1

Frequent Co-Authors

G. J. Schuetz· 5 shared J. B. Huppa· 4 shared E. Sevcsik· 3 shared H. Stockinger· 3 shared R. Platzer· 3 shared E. Kurz· 2 shared F. Baumgart· 2 shared J. Hellmeier· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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5 shared papersBiophysics

G. J. Schuetz

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5 papers

Recent·Most cited

Monomeric agonist peptide/MHCII complexes activate T-cells in an autonomous fashion

R. Platzer, J. Hellmeier, J. Gohring, I. Doel-Perez, P. Schatzlmaier, C. Bodner, G. J. Schuetz, E. Sevcsik, H. Stockinger, M. Brameshuber, J. B. Huppa

The paper uses live cell microscopy to show that monomeric agonist pMHCIIs can activate T-cells autonomously without requiring synaptic engagement or bystander pMHCIIs.

bioRxiv · Mar 13, 2023Immunology

3D single molecule localization microscopy reveals the topography of the immunological synapse at isotropic precision below 15 nm

L. Velas, M. Brameshuber, J. B. Huppa, E. Kurz, M. Dustin, P. Zelger, A. Jesacher, G. J. Schuetz

This study uses 3D-SMLM to measure the cleft size in immunological synapses between T-cells and lipid bilayers, finding distances of 18-31 nm.

bioRxiv · Aug 9, 2021Biophysics

DNA origami demonstrate the unique stimulatory power of single pMHCs as T-cell antigens

J. Hellmeier, R. Platzer, A. S. Eklund, T. Schlichthaerle, A. Karner, V. Motsch, E. Kurz, V. Bamieh, M. Brameshuber, J. Preiner, R. Jungmann, H. Stockinger, G. J. Schuetz, J. B. Huppa, E. Sevcsik

The paper demonstrates that single pMHCs can robustly stimulate T-cells as isolated entities, identifying the minimal requirements for effective TCR-triggering.

Proceedings of the National Academy of Sciences · Jan 19, 2021Peer-reviewedBiophysics

Unscrambling Fluorophore Blinking for Comprehensive Cluster Detection via Photoactivated Localization Microscopy

R. Platzer, B. K. Rossboth, M. C. Schneider, E. Sevcsik, F. Baumgart, H. Stockinger, G. J. Schuetz, J. B. Huppa, M. Brameshuber

The paper develops a method to quantify and correct for fluorophore blinking in PALM to improve cluster detection accuracy.

bioRxiv · May 30, 2020Biophysics

Verifying molecular clusters by 2-color localization microscopy and significance testing

A. M. Arnold, M. C. Schneider, C. Huesson, R. Sablatnig, M. Brameshuber, F. Baumgart, G. J. Schuetz

This paper introduces 2-CLASTA, a statistical method to detect biomolecular clusters in SMLM data, validated through simulations and experiments.

bioRxiv · Nov 29, 2019Biophysics