Author

J. Hellmeier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:microscopy & imaging analysis· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:dimensionality reduction· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:imputation· 1

Frequent Co-Authors

E. Sevcsik· 3 shared G. J. Schuetz· 3 shared J. B. Huppa· 3 shared R. Platzer· 3 shared E. Kurz· 2 shared H. Stockinger· 2 shared M. Brameshuber· 2 shared R. Jungmann· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersBiophysics

E. Sevcsik

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Monomeric agonist peptide/MHCII complexes activate T-cells in an autonomous fashion

R. Platzer, J. Hellmeier, J. Gohring, I. Doel-Perez, P. Schatzlmaier, C. Bodner, G. J. Schuetz, E. Sevcsik, H. Stockinger, M. Brameshuber, J. B. Huppa

The paper uses live cell microscopy to show that monomeric agonist pMHCIIs can activate T-cells autonomously without requiring synaptic engagement or bystander pMHCIIs.

bioRxiv · Mar 13, 2023Immunology

Simultaneous multicolor fluorescence imaging using duplication-based PSF splitting

R. Van den Eynde, F. Hertel, S. Abakumov, B. Krajnik, S. Hugelier, A. Auer, J. Hellmeier, T. Schlichthaerle, R. M. Grattan, D. S. Lidke, R. Jungmann, M. Leutenegger, W. Vandenberg, P. Dedecker

The paper introduces a method to enhance fluorescence imaging by splitting the PSF into multiple copies, enabling simultaneous multicolor imaging with super-resolution and single-molecule capabilities.

bioRxiv · Oct 4, 2022 · PreprintBiophysics

Strategies for the site-specific decoration of DNA origami nanostructures with functionally intact proteins

J. Hellmeier, R. Platzer, V. Muehlgrabner, M. C. Schneider, E. Kurz, G. J. Schuetz, J. B. Huppa, E. Sevcsik

This study evaluates strategies for site-specific decoration of DNA origami with functional proteins, finding that PNA-based conjugation best preserves protein function and stoichiometry.

bioRxiv · Jul 1, 2021Biophysics

DNA origami demonstrate the unique stimulatory power of single pMHCs as T-cell antigens

J. Hellmeier, R. Platzer, A. S. Eklund, T. Schlichthaerle, A. Karner, V. Motsch, E. Kurz, V. Bamieh, M. Brameshuber, J. Preiner, R. Jungmann, H. Stockinger, G. J. Schuetz, J. B. Huppa, E. Sevcsik

The paper demonstrates that single pMHCs can robustly stimulate T-cells as isolated entities, identifying the minimal requirements for effective TCR-triggering.

Proceedings of the National Academy of Sciences · Jan 19, 2021Peer-reviewedBiophysics