Author

M. C. Chao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:whole-genome sequencing· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

E. J. Rubin· 2 shared J. Zhu· 2 shared N. D. Hicks· 2 shared Q. Liu· 2 shared S. M. Fortune· 2 shared S. Stanley· 2 shared X. Wang· 2 shared A. J. Vickers· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersMicrobiology

E. J. Rubin

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

MicrobiologybioRxivPreprintApr 9, 2023

High-throughput phenogenotyping of Mycobacteria tuberculosis clinical strains reveals bacterial determinants of treatment outcomes

S. Stanley, C. N. Spaulding, Q. Liu…·S. M. Fortune

This study uses high-throughput phenogenotyping to link Mtb genetic variants to clinical outcomes, identifying bacterial traits associated with treatment failure and transmission.

DOI 10.1101/2023.04.09.536166

whole-genome sequencingexperimental assay

𝕏 PostBluesky

MicrobiologybioRxivFeb 14, 2023

Chemically-induced targeted protein degradation in mycobacteria uncovers antibacterial effects and potentiates antibiotic efficacy

H. I. Won, J. Zhu, O. Kandror…·E. J. Rubin

This study uses a genetic system to screen essential proteins in Mycobacterium smegmatis, identifying labile targets for PROTACs and showing their potential to enhance antibiotic efficacy.

DOI 10.1038/s41467-024-48506-8

bacteria (other)experimental assay

𝕏 PostBluesky

MicrobiologybioRxivMar 29, 2022

Tuberculosis treatment failure associated with evolution of antibiotic resilience

Q. Liu, J. Zhu, C. L. Dulberger…·S. M. Fortune

The paper identifies resR as a target of positive selection in Mtb clinical isolates, linking its mutations to antibiotic resilience and treatment failure.

DOI 10.1126/science.abq2787

humanwhole-genome sequencing

𝕏 PostBluesky