S. Stanley

Ongoing evolution of the Mycobacterium tuberculosis lactate dehydrogenase reveals the pleiotropic effects of bacterial adaption to host pressure

This study investigates the evolutionary adaptation of Mycobacterium tuberculosis lactate dehydrogenase (LldD2) under host pressure, showing its role in metabolic flexibility and virulence.

Mycobacterial formation of intracellular lipid inclusions is a dynamic process associated with rapid replication

This study shows that mycobacteria form intracellular lipid inclusions during active replication without environmental stressors, challenging the link between ILI and non-replicating persistence.

Tuberculosis susceptibility in genetically diverse mice reveals functional diversity of neutrophils

The paper identifies a novel neutrophil signature associated with poor tuberculosis control in genetically diverse mice.

High-throughput phenogenotyping of Mycobacteria tuberculosis clinical strains reveals bacterial determinants of treatment outcomes

This study uses high-throughput phenogenotyping to link Mtb genetic variants to clinical outcomes, identifying bacterial traits associated with treatment failure and transmission.

MarR-Dependent Transcriptional Regulation of mmpSL5 Induces Ethionamide Resistance in Mycobacterium abscessus

This study identifies MarR as a regulator of ethionamide resistance in Mycobacterium abscessus by showing that marR deletion increases resistance to ethionamide but not other antibiotics.

Cas9+ conditionally immortalized neutrophil progenitors as a tool for genome wide CRISPR screening for neutrophil differentiation and function

This paper introduces a Cas9+ER-Hoxb8 neutrophil progenitor cell line for CRISPR screening to study neutrophil differentiation and function, identifying key genes like Cebpe and the WASH complex.

Tuberculosis treatment failure associated with evolution of antibiotic resilience

The paper identifies resR as a target of positive selection in Mtb clinical isolates, linking its mutations to antibiotic resilience and treatment failure.

The B.1.427/1.429 (epsilon) SARS-CoV-2 variants are more virulent than ancestral B.1 (614G) in Syrian hamsters

This study shows that the B.1.427/1.429 (epsilon) SARS-CoV-2 variants cause more severe disease and higher viral loads in the upper respiratory tract in Syrian hamsters compared to the ancestral B.1 (614G) strain.

An intranasal ASO therapeutic targeting SARS-CoV-2

This paper develops an intranasal ASO therapy targeting SARS-CoV-2 RNA that effectively prevents viral replication in multiple models and variants.

Mucosal vaccination with cyclic-di-nucleotide adjuvants induces effective T cell homing and IL-17 dependent protection against M. tuberculosis infection

This study shows mucosal vaccination with CDN adjuvants induces T cells that home to lungs and provide IL-17-dependent protection against M. tuberculosis.

Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells

This study identifies 20 approved drugs that synergize with remdesivir to inhibit SARS-CoV-2 replication in human lung cells, with HCV NS5A inhibitors showing the strongest effects.

SARS CoV-2 nucleocapsid protein forms condensates with viral genomic RNA

This study shows that SARS-CoV-2 nucleocapsid protein forms condensates with viral RNA in vitro and in cells, driven by hydrophobic and electrostatic interactions.

A nanocompartment containing the peroxidase DypB contributes to defense against oxidative stress in M. tuberculosis

This study identifies a nanocompartment in M. tuberculosis containing DypB that enhances resistance to oxidative stress during infection and antibiotic treatment.

Ancient coding sequences underpin the spatial patterning of gene expression in C4 leaves

The paper identifies two conserved DNA motifs in exons that control spatial gene expression in C4 leaves, showing they are ancient and functionally important for C4 photosynthesis.