BiochemistrybioRxiv
Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling
K. M. Zoltowska, U. Das, S. Lismont…·L. Chavez-Gutierrez
This study shows that human Aβ42 inhibits γ-secretase, leading to substrate accumulation and neuronal dysfunction, suggesting a feedback mechanism in Alzheimer's disease.
DOI 10.7554/elife.90690