M. Carrasquilla

This paper introduces a method to assess fitness and drug resistance in Plasmodium falciparum strains using CRISPR/Cas9 and barcode sequencing, demonstrating its ability to detect artemisinin resistance in mixed parasite populations.

This study uses identity-by-descent analysis on whole-genome sequences from Plasmodium falciparum to examine drug resistance and population structure in a low-transmission, inbred population.

This study quantifies vector uptake in Plasmodium falciparum and finds non-Poissonian transfection dynamics, with parasites taking up multiple vectors early and unevenly.

This paper develops a method to capture in vivo RNA transcriptional dynamics in Plasmodium falciparum by engineering parasites to salvage pyrimidines and label nascent mRNAs, revealing transcriptional reprogramming during gametocyte stage transition.