M. Rawat

Quinoxaline-Based Anti-Schistosomal Compounds Have Potent Anti-Malarial Activity

This study identifies quinoxaline-based anti-schistosomal compounds with potent anti-malarial activity against Plasmodium falciparum, including resistance mechanisms involving pfqrp1 and pfatp2.

Anti-oxidant Response of Lipidom Modulates Lipid Metabolism in Caenorhabditis elegans and in OxLDL-Induced Human Macrophages by Tuning Inflammatory Mediators

This study evaluates the anti-oxidant and lipid-lowering effects of Lipidom in human macrophages and C. elegans, showing reduced inflammation, oxidative stress, and lipid accumulation.

Barcoding genetically distinct Plasmodium falciparum strains for comparative assessment of fitness and antimalarial drug resistance

This paper introduces a method to assess fitness and drug resistance in Plasmodium falciparum strains using CRISPR/Cas9 and barcode sequencing, demonstrating its ability to detect artemisinin resistance in mixed parasite populations.

SARS-COV-2 induced Diarrhea is inflammatory, Ca2+ Dependent and involves activation of calcium activated Cl channels

This study investigates the pathophysiology of SARS-CoV-2-induced diarrhea, showing it is inflammatory, calcium-dependent, and involves activation of calcium-activated chloride channels.

Single Cell RNA-sequencing reveals cellular heterogeneity, stage transition and antigenic variation during stress adaptation in synchronized Plasmodium falciparum

This study uses scRNA-seq to analyze cellular heterogeneity and stress adaptation in Plasmodium falciparum under temperature stress, identifying gametogenesis primed cells and stress response mechanisms.

PfGCN5, a global regulator of stress responsive genes, modulates artemisinin resistance in Plasmodium falciparum

This study identifies PfGCN5 as a global regulator of stress-responsive genes in Plasmodium falciparum that modulates artemisinin resistance by acetylating PfAlba3 and binding to resistance-associated genes.

The bacillithiol pathway is required for biofilm formation in Staphylococcus aureus

This study shows that the bacillithiol pathway and nitric oxide are essential for biofilm formation in Staphylococcus aureus.