iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE
I. Oikonomidi, E. Burbridge, M. Cavadas, G. Sullivan, D. Clancy, B. Collis, J. Brezinova, J. Humpolickova, T. Hu, A. Bileck, C. Gerner, A. Bolado, A. von Kriegsheim, K. Strisovsky, S. J. Martin, C. Adrain
This study identifies iTAP as a novel iRhom interactor that stabilizes iRhom and TACE, essential for TNF secretion, and shows its role in regulating inflammation.
bioRxiv · Jan 30, 2018Biochemistry