A. Bileck

ROS induction as a strategy to target persister cancer cells with low metabolic activity in NRAS mutated melanoma

The paper identifies ROS induction as a strategy to target MEK-inhibitor resistant NRAS-mutated melanoma cells by exploiting their quiescent metabolic state and elevated baseline ROS levels.

Finger Sweat Analysis Enables Short Interval Metabolic Biomonitoring in Humans

This paper demonstrates that finger sweat can be used for short interval metabolic biomonitoring, detecting caffeine metabolites and enabling non-invasive, repeated sampling.

Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8

This study shows that Schwann cells in neuroblastic tumors and injured nerves share repair-related functions, with EGFL8 promoting neuronal differentiation of tumor cells.

Single-cell landscape of bone marrow metastases in human neuroblastoma unraveled by deep multiplex imaging

This study uses deep multiplex imaging to create a single-cell atlas of bone marrow metastases in neuroblastoma, revealing tumor heterogeneity and microenvironmental changes.

Eicosanoid content in fetal calf serum accounts for reproducibility challenges in cell culture

This study identifies eicosanoid batch variations in fetal calf serum as a source of reproducibility issues in cell culture by showing their impact on cellular effector functions.

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE

This study identifies iTAP as a novel iRhom interactor that stabilizes iRhom and TACE, essential for TNF secretion, and shows its role in regulating inflammation.