Semaphorin 4B is an ADAM17-cleaved inhibitor of adipocyte thermogenesis
A. Amin, M. Badenes, J. Tueshaus, E. de Carvalho, E. Burbridge, P. Faisca, K. Travnickova, A. Barros, S. Carobbio, P. Domingos, A. Vidal-Puig, L. F. Moita, S. Maguire, K. Strisovsky, S. F. Lichtenthaler, C. Adrain
This study identifies SEMA4B as an ADAM17-cleaved inhibitor of adipocyte thermogenesis, showing it dampens thermogenic responses and protects against obesity.
bioRxiv · Oct 11, 2022 · PreprintPhysiology