Author

C. Adrain

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 3 Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:proteomics· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:Drosophila· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

K. Strisovsky· 3 shared C. J. Gaspar· 2 shared E. Burbridge· 2 shared P. Domingos· 2 shared A. Amin· 1 shared A. Barros· 1 shared A. Bileck· 1 shared A. Bolado· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersPhysiology

K. Strisovsky

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Ribosome Quality Control Mechanism Mitigates the Cytotoxic Impacts of Ribosome Collisions Induced by 5-Fluorouracil

S. Chatterjee, P. Naeli, N. Simms, A. Garzia, A. Hackett, K. Coyle, P. Harris Snell, T. McGirr, T. N. Sawant, K. Dang, Z. V. Stoichkova, T. Alain, T. Tuschl, S. S. McDade, D. Longley, , S. M. Jafarnejad

This study shows that 5-Fluorouracil induces ribosome collisions, which are mitigated by the RQC mechanism through mTOR-dependent regulation of RQC factors.

bioRxiv · Dec 26, 2023Cell Biology

Semaphorin 4B is an ADAM17-cleaved inhibitor of adipocyte thermogenesis

A. Amin, M. Badenes, J. Tueshaus, E. de Carvalho, E. Burbridge, P. Faisca, K. Travnickova, A. Barros, S. Carobbio, P. Domingos, A. Vidal-Puig, L. F. Moita, S. Maguire, K. Strisovsky, S. F. Lichtenthaler, C. Adrain

This study identifies SEMA4B as an ADAM17-cleaved inhibitor of adipocyte thermogenesis, showing it dampens thermogenic responses and protects against obesity.

bioRxiv · Oct 11, 2022 · PreprintPhysiology

Xport-A functions as a chaperone by stabilizing the first 5 transmembrane domains of Rhodopsin-1

C. J. Gaspar, J. C. Martins, M. N. Melo, T. N. Cordeiro, C. Adrain, P. M. Domingos

The paper proposes a model where Xport-A stabilizes the first 5 transmembrane domains of Rhodopsin-1 during its biosynthesis, acting as a chaperone but not affecting the full-length protein.

bioRxiv · Apr 1, 2022Cell Biology

EMC is required for biogenesis and membrane insertion of Xport-A, an essential chaperone of rhodopsin-1 and the TRP channel

C. J. Gaspar, L. C. Vieira, J. C. Christianson, D. Jakubec, K. Strisovsky, C. Adrain, P. Domingos

The paper identifies Xport-A as an essential chaperone for rhodopsin-1 and TRP channel biogenesis, showing EMC-dependent membrane insertion is required for its function.

bioRxiv · Feb 1, 2021Cell Biology

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE

I. Oikonomidi, E. Burbridge, M. Cavadas, G. Sullivan, D. Clancy, B. Collis, J. Brezinova, J. Humpolickova, T. Hu, A. Bileck, C. Gerner, A. Bolado, A. von Kriegsheim, K. Strisovsky, S. J. Martin, C. Adrain

This study identifies iTAP as a novel iRhom interactor that stabilizes iRhom and TACE, essential for TNF secretion, and shows its role in regulating inflammation.

bioRxiv · Jan 30, 2018Biochemistry