Author

M. Cecchini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Approach:statistical model· 4 Research Focus:protein folding & dynamics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Approach:deep learning· 2 Organism:human· 2 Organism:mouse· 2

Frequent Co-Authors

A. H. Cerdan· 2 shared P.-J. Corringer· 2 shared A. Bartocci· 1 shared A. Bhatt· 1 shared A. Bysice· 1 shared A. Grazzi· 1 shared A. Houdusse· 1 shared A. Prosz· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersBiophysics

A. H. Cerdan

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Author profile →

7 papers

Recent·Most cited

Pannexin 1 and Pannexin 3 differentially regulate the tumorigenic properties of cutaneous squamous cell carcinoma

B. L. O'Donnell, D. Johnston, A. Bhatt, Z. Kardan, D. Stefan, A. Bysice, S. Sayedyahossein, L. Dagnino, M. Cecchini, S. K. Loganathan, K. Roth, S. Penuela

This study investigates the differential roles of PANX1 and PANX3 in cutaneous squamous cell carcinoma, finding PANX1 promotes tumorigenesis while PANX3 suppresses it.

bioRxiv · Apr 8, 2024 · PreprintCancer Biology

A weak coupling mechanism mediates the recovery stroke of myosin VI: a free energy simulation and string method analysis

F. E. C. Blanc, A. Houdusse, M. Cecchini

This paper uses free energy simulations and the string method to analyze the recovery stroke of myosin VI, showing that lever-arm re-priming is driven by thermal fluctuations and weakly coupled to ATP hydrolysis.

bioRxiv · Oct 2, 2023 · PreprintBiophysics

A millisecond coarse-grained simulation approach to decipher allosteric cannabinoid binding at the glycine receptor α1

A. Bartocci, A. Grazzi, N. Awad, P.-J. Corringer, P. C. T. d. Souza, M. CECCHINI

This study uses simulations to identify multiple cannabinoid-binding sites on zebrafish GlyR-1, validating predictions with experiments.

bioRxiv · Apr 19, 2023 · PreprintBiophysics

Diagnostic tool to identify and treat DNA repair deficient gastroesophageal adenocarcinomas

A. Prosz, P. Sahgal, C. X. Morris, Z. Sztupinszki, J. Borcsok, M. Diossy, V. Tisza, S. Spisak, O. Rusz, I. Csabai, B. M. Huffman, H. Singh, J.-B. Lazaro, M. Cecchini, J. M. Cleary, , N. S. Sethi

This study identifies HR and NER deficiencies in gastric and esophageal adenocarcinomas and shows their responsiveness to platinum chemotherapy and PARP inhibitors.

bioRxiv · Jul 14, 2022 · PreprintCancer Biology

Illumination of a progressive allosteric mechanism mediating the glycine receptor activation

S. Shi, S. N. Lefebvre, L. Peverini, A. H. Cerdan, M. Gielen, J.-P. Changeux, M. CECCHINI, P.-J. Corringer

The paper uses fluorescence and simulations to reveal a progressive conformational change in the glycine receptor that precedes channel activation.

bioRxiv · Jun 4, 2022Biophysics

On the functional annotation of open-channel structures in the glycine receptor

A. H. Cerdan, M. Cecchini

The paper evaluates the physiological relevance of open-pore conformations in glycine receptors using electrophysiology and structural data, finding that some models may not reflect true physiological states.

bioRxiv · May 5, 2020Biophysics

Context dependent roles for RB-E2F transcriptional regulation in tumor suppression

F. Dick, M. Thwaites, M. Cecchini, D. Passos

This study shows that RB-E2F transcriptional control defects are not universally cancer-promoting but can enhance cancer susceptibility when combined with specific genetic vulnerabilities.

bioRxiv · Aug 24, 2018Cancer Biology