Author

J.-B. Lazaro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Prosz· 2 shared H. Singh· 2 shared J. M. Cleary· 2 shared N. S. Sethi· 2 shared P. Sahgal· 2 shared S. Spisak· 2 shared V. Tisza· 2 shared Z. Szallasi· 2 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

A. Prosz

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3 papers

Recent·Most cited

Replicative stress in gastroesophageal adenocarcinoma is associated with chromosomal instability and sensitivity to DNA damage response inhibitors.

P. Sahgal, D. T. Patil, Z. Sztupinszki, V. Tisza, S. Spisak, B. Huffman, A. Prosz, H. Singh, J.-B. Lazaro, Z. Szallasi, J. M. Cleary, N. S. Sethi

The paper identifies DDR biomarkers and ploidy abnormalities in GEA that predict sensitivity to DDR inhibitors and premalignant progression.

bioRxiv · Mar 27, 2023 · PreprintCancer Biology

Diagnostic tool to identify and treat DNA repair deficient gastroesophageal adenocarcinomas

A. Prosz, P. Sahgal, C. X. Morris, Z. Sztupinszki, J. Borcsok, M. Diossy, V. Tisza, S. Spisak, O. Rusz, I. Csabai, B. M. Huffman, H. Singh, J.-B. Lazaro, M. Cecchini, J. M. Cleary, , N. S. Sethi

This study identifies HR and NER deficiencies in gastric and esophageal adenocarcinomas and shows their responsiveness to platinum chemotherapy and PARP inhibitors.

bioRxiv · Jul 14, 2022 · PreprintCancer Biology

WRN Helicase is a Synthetic Lethal Target in Microsatellite Unstable Cancers

E. Chan, T. Shibue, J. McFarland, B. Gaeta, J. McPartlan, M. Ghandi, J. B. Liu, J.-B. Lazaro, N. Dumont, A. Gonzalez, A. Apffel, S. O. Ali, L. Leung, E. Roberts, E. Rizvochenko, , A. J. Bass

The paper identifies WRN helicase as a synthetic lethal target in microsatellite unstable cancers through CRISPR/Cas9 and RNAi screens, showing its essentiality in MSI cell lines.

bioRxiv · Dec 21, 2018Cancer Biology