Author

D. Passos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Biswas· 2 shared D. Lyumkis· 2 shared F. Dick· 2 shared M. Li· 2 shared R. Craigie· 2 shared Z. Li· 2 shared Z. Shan· 2 shared A. Haldane· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersBiochemistry

A. Biswas

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Oligomeric HIV-1 Integrase Structures Reveal Functional Plasticity for Intasome Assembly and RNA Binding

T. Jing, Z. Shan, T. Dinh, A. Biswas, S. Jang, J. Greenwood, M. Li, Z. Zhang, G. Gray, H. J. Shin, B. Zhou, D. Passos, T. S. Strutzenberg, S. Aiyer, L. Andrade, , D. Lyumkis

This study determines cryo-EM structures of HIV-1 integrase tetramers and intasome hexadecamers, revealing structural plasticity and functional roles in viral integration and RNA binding.

bioRxiv · Jan 26, 2024 · PreprintBiochemistry

Netrin signaling mediates survival of dormant epithelial ovarian cancer cells

P. Perampalam, J. I. MacDonald, K. Zakirova, D. Passos, S. Wasif, Y. Ramos-Valdes, M. Hervieu, P. Mehlen, R. Rottapel, B. Gibert, R. Correa, T. Shepherd, F. Dick

This study identifies Netrin signaling as critical for survival of dormant high-grade serous ovarian cancer cells and its role in metastasis.

bioRxiv · Aug 29, 2023Cancer Biology

Mechanisms of HIV-1 Integrase Resistance to Dolutegravir and Potent Inhibition of Drug Resistant Variants

M. Li, D. Passos, Z. Shan, S. J. Smith, Q. Sun, A. Biswas, I. Choudhuri, T. Strutzenberg, A. Haldane, N. Deng, Z. Li, X.-Z. Zhao, T. R. Burke, R. M. Levy, S. H. Hughes, , D. Lyumkis

The paper investigates mechanisms of HIV-1 integrase resistance to Dolutegravir and shows that 4d is more effective against resistant variants.

bioRxiv · Dec 4, 2022Biophysics

Context dependent roles for RB-E2F transcriptional regulation in tumor suppression

F. Dick, M. Thwaites, M. Cecchini, D. Passos

This study shows that RB-E2F transcriptional control defects are not universally cancer-promoting but can enhance cancer susceptibility when combined with specific genetic vulnerabilities.

bioRxiv · Aug 24, 2018Cancer Biology