TAZ-CAMTA1 and YAP-TFE3 modulate the basal TAZ/YAP transcriptional program by recruiting the ATAC histone acetyltransferase complex
N. Merritt, K. Garcia, D. Rajendran, Z.-Y. Lin, X. Zhang, K. Mitchell, N. Borcherding, C. Fullenkamp, M. Chimenti, A.-C. Gingras, K. Harvey, M. R. Tanas
This study identifies the ATAC histone acetyltransferase complex as an oncogenic driver in EHE by showing TAZ-CAMTA1 and YAP-TFE3 recruit it to modulate transcription and chromatin structure.
bioRxiv · Sep 7, 2020Cancer Biology