K. Garcia

A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation

This study identifies RNA dynamics as key regulators of cellular response to decitabine in AML cells using a multiomics and CRISPR approach.

Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers

The paper systematically identifies and characterizes cancer-emergent oncRNAs across 32 tumor types, showing they act as blood-accessible molecular barcodes for cancer identity and prognosis.

Integrative identification of non-coding regulatory regions driving metastatic prostate cancer

This study identifies non-coding regulatory regions driving metastatic prostate cancer using an integrative computational and experimental approach.

Inhibition of muscarinic receptor signaling protects human enteric inhibitory neurons against platin chemotherapy toxicity

This study identifies muscarinic receptor signaling as a key driver of platin-induced enteric neuropathy and shows that its inhibition protects neurons from toxicity.

Functional microRNA-Targeting Drug Discovery by Graph-Based Deep Learning

This study develops RiboStrike, a deep learning framework to identify small molecules targeting microRNAs, demonstrating its effectiveness in finding anti-miR-21 compounds with cancer therapeutic potential.

Characterization of Three Variants of SARS-CoV-2 in vivo Shows Host-Dependent Pathogenicity in Hamsters

This study compares the pathogenicity of three SARS-CoV-2 variants in different animal models, showing host-dependent outcomes and the importance of model selection.

A sense-antisense RNA interaction promotes breast cancer metastasis via regulation of NQO1 expression

The paper identifies an antisense RNA, NQO1-AS, that promotes breast cancer metastasis by stabilizing NQO1 mRNA, enhancing oxidative stress tolerance and enabling lung colonization.

An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus

The paper identifies HNRNPC and PABPC4 as regulators of alternative polyadenylation that suppress breast cancer metastasis by controlling mRNA translation.

A systematic comparison of fibroblasts derived from postmortem human dura mater versus dermal epithelium for neurodegenerative disease modeling

This study compares fibroblasts from postmortem human dura mater and dermal epithelium, finding significant differences in morphology, growth, marker expression, and chromosomal abnormalities.

Physiological and transcriptomic response of Medicago truncatula to high and low benefit mycorrhizal fungi

This study compares the physiological and transcriptomic responses of Medicago truncatula to high and low benefit arbuscular mycorrhizal fungi, identifying gene expression differences linked to growth, nutrient uptake, and stress responses.

Identification of a family of Vibrio type III secretion system effectors that contain a conserved serine/threonine kinase domain

The paper identifies a new family of Vibrio type III secretion system effectors containing a conserved serine/threonine kinase domain, found in diverse Vibrio species and Shewanella baltica.

TAZ-CAMTA1 and YAP-TFE3 modulate the basal TAZ/YAP transcriptional program by recruiting the ATAC histone acetyltransferase complex

This study identifies the ATAC histone acetyltransferase complex as an oncogenic driver in EHE by showing TAZ-CAMTA1 and YAP-TFE3 recruit it to modulate transcription and chromatin structure.

Role of Cytosolic, Tyrosine-Insensitive Prephenate Dehydrogenase in Medicago truncatula

This study investigates the role of PDH in Medicago truncatula by analyzing mutants, finding that MtPDH1 contributes to Tyr biosynthesis under stimulated shikimate pathway conditions.