N. Borcherding

Epithelial IL-2 is critical for NK cell-mediated cancer immunosurveillance in mammary glands

The paper identifies epithelial IL-2 as critical for maintaining NK cell function in mammary glands, leading to improved immunosurveillance and prevention of tumor development.

Type I interferon drives a cellular state inert to TCR-stimulation and could impede effective T-cell differentiation in cancer

The paper identifies a subset of CD8+ TILs in HPV-HNSCC enriched for interferon-stimulated genes that are transcriptionally inert to TCR stimulation and may hinder T-cell differentiation.

The distinct roles of MSH2 and MLH1 in basal-like breast cancer and immune modulation

This study identifies distinct roles of MSH2 and MLH1 in basal-like breast cancer, showing MSH2 promotes metastasis while MLH1 enhances it, and reveals MSH2's role in immune modulation through IFNAR1 regulation.

Enhanced survival and low proliferation marks multifunctional virus specific memory CD4 T cells

The paper identifies multifunctional virus-specific memory CD4 T cells that exhibit enhanced survival and low proliferation, suggesting survival, not proliferation, drives their persistence in the memory pool.

Mouse tissue harvest-induced hypoxia rapidly alters the in vivo metabolome, between-genotype metabolite level differences, and 13C-tracing enrichments

The paper shows that post-dissection hypoxia rapidly alters the metabolome, genotype-specific differences, and 13C-tracing enrichments in mouse tissues.

IL-17A-mediated alterations in gut microbiota composition particularly changes in Prevotella abundance, impact Treg function in CNS Autoimmunity

This study shows that IL-17A deficiency in mice leads to increased Tregs and beneficial gut microbes like Prevotella, reducing MS-like disease severity.

Dissecting the Cellular Landscape and Transcriptome Network in Viral Myocarditis by Single-Cell RNA Sequencing

This study uses single-cell RNA sequencing to analyze heart cells from healthy and myocarditic mice, identifying changes in immune and non-immune cell populations and their transcriptomic roles in viral myocarditis.

TAZ-CAMTA1 and YAP-TFE3 modulate the basal TAZ/YAP transcriptional program by recruiting the ATAC histone acetyltransferase complex

This study identifies the ATAC histone acetyltransferase complex as an oncogenic driver in EHE by showing TAZ-CAMTA1 and YAP-TFE3 recruit it to modulate transcription and chromatin structure.

Single cell BCR and transcriptome analysis after respiratory virus infection reveals spatiotemporal dynamics of antigen-specific B cell responses.

The paper analyzes single-cell BCR and transcriptome data from influenza-infected mice to reveal organ-specific B cell dynamics and clonal responses.

Mapping the Immune Landscape of Clear Cell Renal Cell Carcinoma by Single-Cell RNA-seq

This study uses single-cell RNA-seq to characterize immune cell diversity and gene programs in clear cell renal cell carcinoma, identifying distinct immune cell states and clonotypes.

Synergistic interplay between PHF8 and HER2 signaling contributes to breast cancer development and drug resistance

This study identifies a synergistic relationship between PHF8 and HER2 signaling in breast cancer, showing PHF8 promotes HER2 expression and drug resistance.

Transcriptional heterogeneity in cancer-associated regulatory T cells is predictive of survival.

The paper identifies transcriptional subtypes of tumor-infiltrating regulatory T cells and shows that a CD177+ subset predicts poorer survival in renal clear cell carcinoma and other cancers.