Author

M. Doepner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

T. W. Ridky· 2 shared A. Blanco· 1 shared B. C. Capell· 1 shared B. S. Katzenellenbogen· 1 shared C. A. Natale· 1 shared G. Rice· 1 shared I. Y. Lee· 1 shared J. A. Katzenellenbogen· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

T. W. Ridky

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2 papers

Recent·Most cited

Stress vesicles are induced by acute mechanical force and precede the commitment of epidermal stem cells to terminal differentiation

S. Huang, P. Kuri, J. Zou, A. Blanco, M. Marshall, G. Rice, S. Prouty, T. Dentchev, M. Doepner, J. D. Boerckel, B. C. Capell, T. W. Ridky, P. Rompolas

This study shows that mechanical stress induces stress vesicles in epidermal stem cells, which are linked to cell fate and regulated by Piezo1 and calcium dynamics.

bioRxiv · Sep 29, 2022 · PreprintCell Biology

CHRM1 is a Druggable Melanoma Target Whose Endogenous Activity is Determined by Inherited Genetic Variation in DOPA Production

M. Doepner, C. A. Natale, I. Y. Lee, S. Venkat, S. H. Kim, J. A. Katzenellenbogen, B. S. Katzenellenbogen, M. Feigin, T. W. Ridky

This study identifies CHRM1 as a druggable melanoma target influenced by genetic variation in DOPA production, showing DOPA inhibits CHRM1 to suppress melanoma proliferation.

bioRxiv · Mar 3, 2021 · PreprintCancer Biology