Cancer BiologybioRxivPreprint
CHRM1 is a Druggable Melanoma Target Whose Endogenous Activity is Determined by Inherited Genetic Variation in DOPA Production
M. Doepner, C. A. Natale, I. Y. Lee…·T. W. Ridky
This study identifies CHRM1 as a druggable melanoma target influenced by genetic variation in DOPA production, showing DOPA inhibits CHRM1 to suppress melanoma proliferation.
DOI 10.1101/2021.03.03.433757