T. W. Ridky

This study uses immunohistochemistry with a new antibody to show GPER expression varies across normal and cancer tissues.

This study shows that mechanical stress induces stress vesicles in epidermal stem cells, which are linked to cell fate and regulated by Piezo1 and calcium dynamics.

This study identifies CHRM1 as a druggable melanoma target influenced by genetic variation in DOPA production, showing DOPA inhibits CHRM1 to suppress melanoma proliferation.

The paper identifies ZIP9 as a target of testosterone in melanoma and shows that androgen receptor inhibitors can block ZIP9 to suppress melanoma growth in males.

This study shows that GPER activation inhibits melanoma growth and enhances response to PD-1 blockade by promoting differentiation and reducing immune suppressive proteins.