A. Blanco

Monocyte to macrophage differentiation and changes in cellular redox homeostasis promote cell type-specific HIV latency reactivation

This study shows that monocyte-to-macrophage differentiation and redox changes influence HIV latency differently in cell types, with macrophages being more responsive to redox modulators.

β-carotene accelerates the resolution of atherosclerosis in mice

This study shows that β-carotene accelerates atherosclerosis resolution in mice without affecting body weight or plasma lipid levels.

Stress vesicles are induced by acute mechanical force and precede the commitment of epidermal stem cells to terminal differentiation

This study shows that mechanical stress induces stress vesicles in epidermal stem cells, which are linked to cell fate and regulated by Piezo1 and calcium dynamics.

Kinase Suppressor of RAS 1 (KSR1) maintains the transformed phenotype of BRAFV600E mutant human melanoma cells

This study shows that KSR1 is essential for maintaining the transformed phenotype of BRAFV600E mutant melanoma cells by promoting cell survival and inhibiting senescence and apoptosis.

The unique Brucella effectors NyxA and NyxB target SENP3 to modulate the subcellular localisation of nucleolar proteins

This study shows that Brucella effectors NyxA and NyxB target SENP3 to alter nucleolar protein localization, promoting bacterial replication.

Larger organ size caused by obesity is a mechanism for higher cancer risk.

This study shows that obesity increases organ size, which correlates with higher cancer risk due to more cells at risk of becoming cancerous.

Senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and cartilage regeneration in osteoarthritis

This study shows that olive-derived polyphenols like oleuropein target Cx43 and senescence in osteoarthritis cells, promoting cartilage regeneration and reducing inflammation.