Author

M. E. Bowman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Organism:plant (other)· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

J. P. Noel· 2 shared A. Mehrani· 1 shared A. Pabis· 1 shared A. T. Nelson· 1 shared B. A. Barad· 1 shared D. Grotjahn· 1 shared D. Lyumkis· 1 shared D. O. Passos· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiophysics

J. P. Noel

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Author profile →

2 papers

Recent·Most cited

Overcoming Resolution Attenuation During Tilted Cryo-EM Data Collection

S. Aiyer, P. R. Baldwin, S. M. Tan, Z. Shan, J. Oh, A. Mehrani, M. E. Bowman, G. Louie, D. O. Passos, S. Đorđevic-Marquardt, M. Mietzsch, J. A. Hull, S. Hoshika, B. A. Barad, D. Grotjahn, , D. Lyumkis

This study improves cryo-EM data collection by reducing resolution attenuation during stage tilt, enabling isotropic map reconstruction of specimens with preferred orientations.

bioRxiv · Jul 14, 2023Biophysics

Bifunctional Substrate Activation via an Arginine Residue Drives Catalysis in Chalcone Isomerases

J. R. Burke, J. J. LaClair, R. N. Philippe, A. Pabis, J. M. Jez, G. A. Cortina, M. Kaltenbach, M. E. Bowman, G. V. Louie, K. B. Woods, A. T. Nelson, D. S. Tawfik, S. C. L. Kamerlin, J. P. Noel

The paper elucidates the catalytic mechanism of chalcone isomerases, showing how an arginine residue activates substrates via Bronsted and Lewis acid interactions, and highlights structural differences between type-1 and type-2 enzymes.

bioRxiv · Oct 30, 2018Biochemistry