Author

M. Mietzsch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

M. Agbandje-Mckenna· 3 shared D. Lyumkis· 2 shared J. A. Hull· 2 shared R. McKenna· 2 shared S. Aiyer· 2 shared Y. Z. Tan· 2 shared A. Mehrani· 1 shared B. A. Barad· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiophysics

M. Agbandje-Mckenna

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Overcoming Resolution Attenuation During Tilted Cryo-EM Data Collection

S. Aiyer, P. R. Baldwin, S. M. Tan, Z. Shan, J. Oh, A. Mehrani, M. E. Bowman, G. Louie, D. O. Passos, S. Đorđevic-Marquardt, M. Mietzsch, J. A. Hull, S. Hoshika, B. A. Barad, D. Grotjahn, , D. Lyumkis

This study improves cryo-EM data collection by reducing resolution attenuation during stage tilt, enabling isotropic map reconstruction of specimens with preferred orientations.

bioRxiv · Jul 14, 2023Biophysics

AAV Capsid Chimeras with Enhanced Infectivity reveal a core element in the AAV Genome critical for both Cell Transduction and Capsid Assembly

L. Viney, T. Bürckstümmer, M. Mietzsch, M. Choudhry, T. Henley, M. Agbandje-McKenna

This paper develops an AAV chimera, AAV-XV, with enhanced T cell transduction efficiency at lower doses and identifies a critical genomic region for both capsid assembly and transduction.

bioRxiv · Oct 13, 2020Cell Biology

Sub-2 A Ewald Curvature Corrected Single-Particle Cryo-EM

Y. Z. Tan, S. Aiyer, M. Mietzsch, J. A. Hull, R. McKenna, J. Grieger, R. J. Samulski, T. S. Baker, M. Agbandje-McKenna, D. Lyumkis

The paper improves cryo-EM resolution by correcting Ewald sphere curvature, achieving 1.86 Å resolution for an AAV2 variant.

Nature Communications · Sep 7, 2018Peer-reviewedBiophysics