Author

Z. Shan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Cell Biology· 1 Microbiology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Assay:cryo-EM· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:protein structure prediction· 2 Organism:bacteria (other)· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

D. Lyumkis· 4 shared A. Biswas· 2 shared A. N. Engelman· 2 shared D. Passos· 2 shared M. Li· 2 shared R. Craigie· 2 shared S. Aiyer· 2 shared Z. Li· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersBiochemistry

D. Lyumkis

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Oligomeric HIV-1 Integrase Structures Reveal Functional Plasticity for Intasome Assembly and RNA Binding

T. Jing, Z. Shan, T. Dinh, A. Biswas, S. Jang, J. Greenwood, M. Li, Z. Zhang, G. Gray, H. J. Shin, B. Zhou, D. Passos, T. S. Strutzenberg, S. Aiyer, L. Andrade, , D. Lyumkis

This study determines cryo-EM structures of HIV-1 integrase tetramers and intasome hexadecamers, revealing structural plasticity and functional roles in viral integration and RNA binding.

bioRxiv · Jan 26, 2024 · PreprintBiochemistry

Peptidoglycan-Chi3l1 interaction shapes gut microbiota in intestinal mucus layer

Y. Chen, R. Yang, B. Qi, Z. Shan

This study identifies Chi3l1 as a host protein that interacts with bacterial peptidoglycan in the gut mucus to regulate microbiota composition and prevent colitis.

bioRxiv · Oct 3, 2023Microbiology

Overcoming Resolution Attenuation During Tilted Cryo-EM Data Collection

S. Aiyer, P. R. Baldwin, S. M. Tan, Z. Shan, J. Oh, A. Mehrani, M. E. Bowman, G. Louie, D. O. Passos, S. Đorđevic-Marquardt, M. Mietzsch, J. A. Hull, S. Hoshika, B. A. Barad, D. Grotjahn, , D. Lyumkis

This study improves cryo-EM data collection by reducing resolution attenuation during stage tilt, enabling isotropic map reconstruction of specimens with preferred orientations.

bioRxiv · Jul 14, 2023Biophysics

Mechanisms of HIV-1 Integrase Resistance to Dolutegravir and Potent Inhibition of Drug Resistant Variants

M. Li, D. Passos, Z. Shan, S. J. Smith, Q. Sun, A. Biswas, I. Choudhuri, T. Strutzenberg, A. Haldane, N. Deng, Z. Li, X.-Z. Zhao, T. R. Burke, R. M. Levy, S. H. Hughes, , D. Lyumkis

The paper investigates mechanisms of HIV-1 integrase resistance to Dolutegravir and shows that 4d is more effective against resistant variants.

bioRxiv · Dec 4, 2022Biophysics

Multivalent interactions essential for lentiviral integrase function

A. Ballandras-Colas, V. Chivukula, D. T. Gruszka, Z. Shan, P. K. Singh, V. E. Pye, R. K. McLean, G. J. Bedwell, W. Li, A. Nans, N. J. Cook, H. J. Fadel, E. M. Poeschla, D. J. Griffiths, J. Vargas, , P. Cherepanov

This study reports cryo-EM structures of the lentiviral intasome and shows that multivalent interactions are essential for integrase function and virus infectivity.

bioRxiv · Jan 26, 2022Biochemistry

Chitinase 3-like-1 Contributes to Acetaminophen-induced Liver Injury by Promoting Hepatic Platelet Recruitment

Z. Shan, L. Li, C. L. Atkins, M. Wang, Y. Wen, J. Jeong, N. Moreno, D. Feng, X. Gui, N. Zhang, C. G. Lee, J. A. Elias, W. Lee, B. Gao, F. W. Lam, , C. Ju

This study identifies Chi3l1 as a key mediator of acetaminophen-induced liver injury by promoting hepatic platelet recruitment through the CD44 axis.

bioRxiv · Apr 8, 2021Pharmacology & Toxicology

Local Metabolism of Ethanol to Acetic Acid/Acetate in the Central Nucleus of Amygdala Elicits Sympathoexcitatory Responses through Activation of NMDAR in Sprague Dawley Rats

A. Chapp, M. Huber, A. R. Collins, K. Driscoll, J. Behnke, R. Larson, Z. Shan, L. Zhang, Q. Chen

This study shows ethanol metabolism in the CeA to acetate activates NMDAR, causing sympathoexcitation in rats.

bioRxiv · Jul 20, 2020 · PreprintPhysiology

Circ_0005962 functions as an oncogene to aggravate non-small cell lung cancer progression via circ_0005962/miR-382-5p/PDK4 regulatory network

Z. Zhang, Z. Shan, R. Chen, X. Peng, B. Xu, L. Xiao, G. Zhang

This study identifies circ_0005962 as an oncogene in NSCLC that promotes progression via the circ_0005962/miR-382-5p/PDK4 regulatory network.

bioRxiv · Mar 6, 2020 · PreprintCell Biology