Author

S. Aiyer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:cryo-EM· 3 Research Focus:protein structure prediction· 3 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

D. Lyumkis· 4 shared J. A. Hull· 2 shared M. Agbandje-Mckenna· 2 shared M. Mietzsch· 2 shared R. McKenna· 2 shared Y. Z. Tan· 2 shared Z. Shan· 2 shared A. Biswas· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersBiophysics

D. Lyumkis

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Author profile →

5 papers

Recent·Most cited

Assembly of the Bacterial Ribosome with Circularly Permuted rRNA

J. R. Williamson, X. Dong, K. Sheng, L. F. R. Gebert, S. Aiyer, I. MacRae, D. Lyumkis

This study investigates bacterial ribosome assembly using circularly permuted rRNAs, revealing conserved assembly routes and domain association order.

bioRxiv · Apr 10, 2024Biophysics

Oligomeric HIV-1 Integrase Structures Reveal Functional Plasticity for Intasome Assembly and RNA Binding

T. Jing, Z. Shan, T. Dinh, A. Biswas, S. Jang, J. Greenwood, M. Li, Z. Zhang, G. Gray, H. J. Shin, B. Zhou, D. Passos, T. S. Strutzenberg, S. Aiyer, L. Andrade, , D. Lyumkis

This study determines cryo-EM structures of HIV-1 integrase tetramers and intasome hexadecamers, revealing structural plasticity and functional roles in viral integration and RNA binding.

bioRxiv · Jan 26, 2024 · PreprintBiochemistry

Overcoming Resolution Attenuation During Tilted Cryo-EM Data Collection

S. Aiyer, P. R. Baldwin, S. M. Tan, Z. Shan, J. Oh, A. Mehrani, M. E. Bowman, G. Louie, D. O. Passos, S. Đorđevic-Marquardt, M. Mietzsch, J. A. Hull, S. Hoshika, B. A. Barad, D. Grotjahn, , D. Lyumkis

This study improves cryo-EM data collection by reducing resolution attenuation during stage tilt, enabling isotropic map reconstruction of specimens with preferred orientations.

bioRxiv · Jul 14, 2023Biophysics

A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins

S. Aiyer, G. V. T. Swapna, G. Liu, L.-C. Ma, J. Hao, G. Chalmers, B. Jacobs, G. T. Montelione, M. J. Roth

This paper investigates the structural interactions of the BRD3 ET domain with host and viral proteins, revealing polymorphic structural interfaces and conformational plasticity.

bioRxiv · Sep 21, 2020Microbiology

Sub-2 A Ewald Curvature Corrected Single-Particle Cryo-EM

Y. Z. Tan, S. Aiyer, M. Mietzsch, J. A. Hull, R. McKenna, J. Grieger, R. J. Samulski, T. S. Baker, M. Agbandje-McKenna, D. Lyumkis

The paper improves cryo-EM resolution by correcting Ewald sphere curvature, achieving 1.86 Å resolution for an AAV2 variant.

Nature Communications · Sep 7, 2018Peer-reviewedBiophysics