MicrobiologybioRxiv
A general computational design strategy for stabilizing viral class I fusion proteins
K. J. Gonzalez, J. Huang, M. F. Criado…·E. M. Strauch
This paper presents a computational strategy to stabilize viral class I fusion proteins by designing mutations that favor the prefusion state over the postfusion state, validated through structural and immunological testing.
DOI 10.1038/s41467-024-45480-z