S. M. Tompkins

This study shows that swine influenza A viruses with the pandemic H1N1 origin matrix gene cause more severe disease in mice compared to those with the classical swine matrix gene.

This paper presents a computational strategy to stabilize viral class I fusion proteins by designing mutations that favor the prefusion state over the postfusion state, validated through structural and immunological testing.

This study shows that feline coronavirus-infected cats develop cross-reactive antibodies to SARS-CoV-2 RBD, despite low sequence similarity, suggesting potential for a pan-CoV vaccine.

This study shows 4-Fluorouridine effectively treats seasonal and highly pathogenic influenza viruses in cell culture, organoids, and animal models, preventing lethal infection and transmission.

This paper evaluates the immunogenicity and efficacy of PIV5-vectored COVID-19 vaccines against SARS-CoV-2 variants in hamsters, showing they induce strong neutralizing antibodies and provide protection as single doses or boosters.

This paper develops a low-dose triple antibody cocktail targeting the conserved M2e antigen of influenza A, showing universal efficacy and resistance to viral escape mutants in mouse models.

This study shows SARS-CoV-2 RBD binds sialylated glycans, particularly gangliosides, and that reducing cell surface sialic acid decreases viral entry.

This study evaluates a MinION-based sequencing method for detecting and characterizing RNA viruses using random priming and strand-switching, showing its effectiveness for known and unknown viruses.

This study identifies heparan sulfate proteoglycans as an attachment factor for SARS-CoV-2 and suggests HS oligosaccharides could inhibit viral binding.