Author

M. Foth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

A. D. Campbell· 1 shared A. F. Munro· 1 shared B. Serrels· 1 shared C. A. Ford· 1 shared C. Bull· 1 shared C. M. Stehn· 1 shared C. Nixon· 1 shared D. A. Kircher· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. D. Campbell

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2 papers

Recent·Most cited

A targetable PREX2/RAC1/PI3Kβ signalling axis confers resistance to clinically relevant therapeutic approaches in melanoma

C. A. Ford, D. Koludrovic, P. P. Centeno, M. Foth, E. Tsonou, N. Vlahov, N. Sphyris, K. Gilroy, C. Bull, C. Nixon, B. Serrels, A. F. Munro, J. C. Dawson, N. O. Carragher, V. Pavet, , A. D. Campbell

This study identifies a druggable PREX2/RAC1/PI3Kβ signalling axis in BRAF-mutant melanoma that confers resistance to therapies and can be targeted to improve treatment outcomes.

bioRxiv · Feb 26, 2024Cancer Biology

Genetic silencing of AKT induces melanoma cell death

G. L. Parkman, T. Turapov, D. A. Kircher, W. J. Burnett, C. M. Stehn, K. T. O'Toole, R. Flaherty, R. C. Elmer, K. M. Culver, M. Foth, R. Andtbacka, D. H. Lum, R. L. Judson-Torres, M. W. VanBrocklin, S. L. Holmen, M. McMahon

This study shows that genetic silencing of AKT paralogs in melanoma cells leads to cell death via mTORC signaling disruption, which can be rescued by activated SGK1, suggesting dual targeting of AKT and SGK1 as a potential therapy.

bioRxiv · Aug 15, 2022 · PreprintCancer Biology