M. McMahon

Cell migration simulator-based biomarkers for glioblastoma

This paper develops a physics-based cell migration simulator to identify physical biomarkers for glioblastoma, linking mechanical parameters to transcriptomic data and drug response.

Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer

This study shows that combining ULK1/2 inhibition with KRASG12C inhibitors reduces lung cancer growth in preclinical models.

Immunity induced by vaccination with recombinant influenza B virus neuraminidase protein breaks viral transmission chains in guinea pigs in an exposure intensity-dependent manner

This study shows that an intranasal recombinant influenza B virus neuraminidase vaccine can block viral transmission in guinea pigs depending on exposure intensity.

Genetic silencing of AKT induces melanoma cell death

This study shows that genetic silencing of AKT paralogs in melanoma cells leads to cell death via mTORC signaling disruption, which can be rescued by activated SGK1, suggesting dual targeting of AKT and SGK1 as a potential therapy.

"Transposon Mutagenesis Reveals RBMS3 as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis."

This paper identifies RBMS3 as a tumor suppressor that cooperates with BRAFV600E to promote malignant lung cancer progression using transposon mutagenesis and CRISPR validation.

Novel epitopes of human monoclonal antibodies targeting the influenza virus N1 neuraminidase

This study identifies novel epitopes of human monoclonal antibodies targeting the influenza virus N1 neuraminidase and characterizes escape mutations and their impact on viral fitness.

Constitutive UPRER activation sustains tumor cell differentiation

The paper shows that constitutive IRE1 activation maintains differentiation in glioblastoma cells by repressing stemness factors.

Measuring physiological responses to stressors using a novel Hmox1 reporter mouse

This paper develops a novel Hmox1 reporter mouse to measure physiological responses to stressors, showing it accurately reflects oxidative and inflammatory stimuli.